Connect with us

HEALTH

Genes will decide how coronavirus will affect you seriously

Published

on

Geneticists from all over the world intend to carry out hundreds of thousands of genetic analyzes to find out what distinguishes the patients who evolve worse

Since the start of the pandemic, everyone has been wondering why the same virus causes such different reactions. While many people do not even know they are infected, others end up in the ICU, and thousands are dying. Some risk factors are clear: advanced age and suffering from other diseases mean that we buy more ballots to suffer a more serious version of Covid-19, but being young and healthy does not guarantee that we will get rid of it either.

Geneticists have thought that their specialty has a lot to contribute, that the different faces of the disease could be related to genetic variability between some individuals and others, as it is in other diseases. Could it be the same with the new coronavirus? To find out, experts have created The Covid-19 Host Genetics Initiative, an international platform to push forward studies on coronavirus patients and share the results. Knowing whether genes make a patient more vulnerable can be key in prognosis and treatment, and would end up saving many lives.

Of these, there will be 7,000 Spaniards and another 1,000 from the United Kingdom, Mexico, Brazil, Argentina, Uruguay, and Colombia that will serve to identify whether the possible genetic markers found are characteristic of Spain or not. In principle, they will not study the complete genome of each individual but certain markers (what is technically called the ‘complete genome association study’ or GWAS). Later, they will sequence 300 complete genomes to analyze in detail the alterations found.

“When we talk about genes, one thinks of rare diseases or cancer, but all human pathologies are the result of the environment and of the person, and also in viral infections, genetics has a lot to say,” explains Pablo Lapunzina in statements to Teknautas. An individual’s genetic information “can make their response to an infection different and even prevent them from becoming infected.” The case of HIV is well known, especially since in November 2018 a Chinese scientist announced that he had genetically modified human embryos to make them resistant, which is why he was later convicted.

With respect to Covid-19, “we are facing a viral infection that should be banal because of every 100 people, close to 80% are asymptomatic, nor do they find out that they were sick, 10 or 15% feel greasy and only one 5% have a severe illness, so it is clear that the individual response is quite different, “says Pablo Lapunzina.

“Without a doubt, the genetic variants have to do with increased risks or protection against the disease, ” he says, although the answer will probably be very complex, the key will not be in a single gene. Many small differences may explain why some people who come in contact with the virus develop serious illness, while most have flu-like symptoms or not even that. “It is also quite likely that there will be people who will not directly become infected even if they are in contact with the virus because it cannot enter the cells, but this will be more difficult to prove,” he says.

As he explains, there is already some data that indicates that the European population could have a greater predisposition to be attacked by the virus, in particular, “variants in the ACE receptors of cells with respect to Asian populations.” The data says that mortality in China was very low compared to that recorded in Europe and, “apart from the fact that epidemiological policies to control the disease have been different, these receptors are likely to be decisive,” he says.

However, it will take hundreds of thousands of patients to confirm that these subtle genetic differences protect or make people more vulnerable. The international consortium aims to reach 150,000. The problem is to make a balanced and correct selection of the participants. “We need to have people who have been infected and have been asymptomatic, and this must be verified with antibody tests; also to others who have been regular, with fever and few more signs of illness, and others who, in the same situation, have been serious or have died, apparently without risk factors, “he explains.

The healthy young man who ends up in the ICU

All the projects included in The Covid-19 Host Genetics Initiative will provide minimal information that is useful for data sharing, but each one has its own particular characteristics. For example, another Spaniard focuses on patients under the age of 60 without other diseases. Led by the CSIC’s Barcelona Institute for Biomedical Research (IIBB), it will focus on 200 patients waiting to obtain more funding.

“We are interested in all patients, but obviously age and previous pathologies are more vulnerable even to the normal flu, so when doing a genetic study, they could lead us to confusion,” says Anna Planas, coordinator of this study. “In the normal population, there are polymorphisms or genetic variations that normally do not entail any pathology, but in the face of a viral infection, there may be people with a poorer response capacity and we can better identify this factor if we focus the study on people initially healthy ”, he highlights.

Already in the first coronavirus epidemic, the SARS epidemic of 2002-2003, some studies pointed out that having certain polymorphisms could increase the susceptibility to severe forms of the disease. However, they were performed with very few patients and almost primitive genetic tools compared to current means. “This encouraged us to think that with the advances of today, we could further explore this issue,” says the researcher.

In Granada, Marta Alarcón Riquelme, a scientist at the Center for Genomics and Oncology Research (Genyo), also wondered why young and middle-aged people developed bilateral pneumonia that characterizes the worst version of Covid-19 and, in particular, by that in the worst cases an inflammation occurs that complicates the condition of the patients.

The challenge of explaining decisive inflammation

In fact, physicians agree to observe a common characteristic among Covid-19 cases that have evolved poorly. Generally, in a first phase, patients have symptoms that could be assimilated to those of the flu, but after a few days, something goes wrong and the immune system overreacts, causing what is called a ‘cytokine storm’, proteins that they should fight the infection but in this case, they cause an inflammation of the organs, especially the lungs.

“We want to know if there is any type of predisposition that is not clinically evident, inflammatory processes that we can detect in DNA by looking for gene expression markers through what is called methylation, and identify possible genetic associations that tell us about a susceptibility to develop more severe disease, “says Marta Alarcón. For example, “I can have a gene with a variant that causes more cytokines to be produced, so the response is going to be greater.” Therefore, it is not about having or not having a gene, but about quantitative changes.

The key is to compare, among hospitalized patients, those who have a worse evolution with those who better overcome the disease. For this, the Genyo is already recruiting patients and the initial idea is to carry out the study with 1,300 participants, in collaboration with other geneticists from Valladolid, Barcelona, ​​Malaga, and Milan.

Although within the international consortium ” 90% of the groups still do not have data “, because they are looking for patients who can participate, Alarcón regrets the bureaucratic obstacles that have prevented him from speeding up the process. “Unfortunately, I have a limit of 15,000 euros to buy material. From this figure, I have to open a public offer that may take a while and I cannot start at this time because we are with the administrative deadlines closed. ” Meanwhile, “in the United States, they are already ahead.”

The application of the results

With more or less Spanish input, experts are confident that the international consortium as a whole will provide decisive data to fight the new coronavirus and that the results can be applied on several fronts. For example, “if a person becomes ill, with a genetic study we would know in 24 hours if their risk is high or low, and based on that we could decide on their income, their follow-up or even analyze the risk that their relatives run”, Lapunzina comments.

On the other hand, genetic information can also be decisive in treatment. First, in the search for new compounds or drugs that are already on the market and can be reused. On the other, to guide the medication of each patient. In fact, something similar happened until recently with hepatitis C – before new treatments became available – patients’ genetic markers were studied to find out who would respond to available treatments. It was a simple study that cost 16 euros and anticipated the effect of the drugs.

“Today, a patient is admitted and ‘a priori’ it is not possible to know if after four days he will go home or have to be admitted to the ICU, there is nothing that can predict this, ” says Anna Planas. However, after these studies, “in an ideal situation, we would find a key gene and know that people who had some variants of it would be more likely to develop a more serious disease.” The reality will be more complicated, but the CSIC researcher believes that “a test could be carried out on the general population with a drop of blood”, knowing that “if a person has a certain polymorphism, he is part of the population that must be to protect”.

The researcher believes that this could also be revolutionary in relation to epidemiological policies. “At the moment, we are talking theoretically, but if we had the entire population studied, we would know what percentage is at risk,” he says. In this sense, it would be possible to develop an epidemiological strategy that would not go through “blind” confinement like the current one, since “we do not know which are the biomarkers that cause us to pass the infection asymptomatically and which are the ones that cause us to be at serious risk ”, but it could be done much more selectively.

However, not everything will be in the genes. For example, among the population differences, there is the fact that men accumulate many more serious cases and deaths. The researchers do not rule out that massive genetic analyzes give any answer, but they believe that it most likely has nothing to do with it. “There are many variables, men tend to be more overweight, hypertensive, and have diabetes. And surely there is a hormonal factor, it seems that women’s estrogens protect a little more. If you remove all those factors, it is likely that the genetic difference between men and women will not make much difference, “Lapunzina points out.

Continue Reading

HEALTH

Keto Breads and Pastries

Published

on

Keto Breads and Pastries

In any case, information about it demonstrating viable for Autism, Type II Diabetes, Weight Loss, and different problems have been arising on the grounds that it is additionally being investigated for different employments. The Keto Diet’s prevalence has expanded worldwide and is viewed as perhaps the most well known eating regimens by master.

It appears as though everyone is attempting the pattern as thousands have shown their change. Indeed, even the Ketogenic Diet was first known as a treatment for epilepsy during the 1920s and 30sn famous people and wellness lovers depended on how powerful the eating regimen is. It is no big surprise different plans are flooding the web and various books have been distributed also.

The Keto Diet includes decreasing starch admission and increasing fat admission. This powers the body to utilize an alternate sort of fuel. Rather than depending on sugar that comes from starches, it consumes fat as fuel. This implies you ought to stay away from food varieties that are a lot higher in carbs, similar to rice, bread, doughnut, cakes, and pasta, and should zero in on eating meat, eggs, and vegetables developing over the ground.

Presently this might feel like a type of hardship, uniquely that the referenced food sources over that you ought to stay away from being considered as solace food sources, food varieties that are eaten to compensate yourself or to simply help you to have an improved outlook.

Presently envision surrendering bread or treats since it is against the Keto Diet plan. Is it worth it to surrender that glad inebriation you get just subsequent to taking that first nibble of bread or that flavorful pastry you have forever been longing for? Could it be said that you will give up those yummy treats to make sure it won’t add creeps to your waistline?

Consider the possibility that, there is a method for following the Keto Diet while partaking in the entirety of your cherished bread and pastries as well. The Keto Diet is really famous on the grounds that they work, it is an amazing asset for weight reduction and can likewise give you significant medical advantages. Presently think briefly that you can accomplish your fantasy body and still appreciate newly heated breads and recently pre-arranged sweets. IT IS POSSIBLE!

In any case, information about it demonstrating viable for Autism, Type II Diabetes, Weight Loss, and different problems have been arising on the grounds that it is additionally being investigated for different employments. The Keto Diet’s prevalence has expanded worldwide and is viewed as perhaps the most well known eating regimen by the master.

It appears as though everyone is attempting the pattern as thousands have shown their change. Indeed, even the Ketogenic Diet was first known as a treatment for epilepsy during the 1920s and 30sn famous people and wellness lovers depended on how powerful the eating regimen is. It is no big surprise different plans are flooding the web and various books have been distributed also.

The Keto Diet includes decreasing starch admission and increasing fat admission. This powers the body to utilize an alternate sort of fuel. Rather than depending on sugar that comes from starches, it consumes fat as fuel. This implies you ought to stay away from food varieties that are a lot higher in carbs, similar to rice, bread, doughnut, cakes, and pasta, and should zero in on eating meat, eggs, and vegetables developing over the ground.

Presently this might feel like a type of hardship, uniquely that the referenced food sources over that you ought to stay away from being considered as solace food sources, food varieties that are eaten to compensate yourself or to simply help you to have an improved outlook.

Presently envision surrendering bread or treats since it is against the Keto Diet plan. Is it worth it to surrender that glad inebriation you get just subsequent to taking that first nibble of bread or that flavorful pastry you have forever been longing for? Could it be said that you will give up those yummy treats to make sure they won’t add creeps to your waistline?

Consider the possibility that, there is a method for following the Keto Diet while partaking in the entirety of your cherished bread and pastries as well. The Keto Diet is really famous on the grounds that they work, it is an amazing asset for weight reduction and can likewise give you significant medical advantages. Presently think briefly that you can accomplish your fantasy body and still appreciate newly heated breads and recently pre-arranged sweets. IT

 IS POSSIBLE!

Continue Reading

HEALTH

Six Reasons to Purchase Health Coverage Throughout COVID-19

Published

on

The Covid-19 outbreak has been challenging in many ways. It has encouraged individuals to understand the importance of wellness and educated them on how to properly care for their own and their dear ones’ fitness. Because India is one of the nations worst affected by the outbreak, the health coverage industry has seen a significant surge in popularity. Individuals have begun to be concerned regarding the financial consequences of a medical crisis, which is because they are investing to purchase the best health insurance for parents in India.

Staying safeguarded is the most important concern, with over 3 lakh existing infections throughout India only. Healthcare insurance acts as a monetary support system for you and your household in the event of a healthcare emergency.

It is fair to say that, since the outbreak of the worldwide outbreak, obtaining health coverage is becoming the accepted norm. Individuals are becoming more accepting of this emerging standard, as practically each insurance company has begun to cover individuals with Covid-19 sickness, as well as a multitude of other disorders.

A few reasons why you should choose health care coverage throughout Covid periods are listed below.

  1. Offers all-encompassing coverage

Emergency situations never occur at a convenient time, which is why individuals purchase healthcare insurance. Choosing a healthcare insurance package protects your family in tough moments while also providing complete protection against all major body disorders.

Furthermore, another explanation why individuals should get healthcare coverage throughout these moments is that health care reimbursement can offer substantial protection against Coronavirus and significantly lower hospital costs.

  1. Increasing medical costs

One of the explanations why more and several individuals are choosing healthcare insurance policies throughout the Covid period is the surge in healthcare prices. As a result of the rising need for healthcare operations, the cost of healthcare services has accelerated, and many are choosing for something like a cashless healthcare coverage program to reduce their hospital bills.

  1. Protection for an entire lifespan

Individuals are choosing healthcare protection coverage that offers them lifelong media attention in light of the current circumstances.

While insurance companies used to restrict treatment at 70 to 80 years, numerous companies now offer healthcare protection that covers you for the rest of your life.

As a result, if you don’t already possess one, you should get one as soon as possible throughout Covid.

  1. Offers a variety of tax advantages

Buying healthcare insurance provides tax benefits as well. Clause 80D of the Income Tax Regulations of 1971 specifically excludes and considers all payments spent for a healthcare insurance coverage as tax benefits.

As a result, whether you pay for healthcare coverage premiums for yourself, your mom and dad, spouse, or children, you can claim a tax deduction.

  1. Additional benefits for riders

Another advantage of purchasing healthcare coverage is that you may simply add additional rider advantages to your current coverage. These added rider advantages might include protection in the event that you become contaminated with the Coronavirus, which would reimburse all of your hospital costs in the event of an urgent situation.

Additionally, practically each insurance company offers these extra advantages, and they could be simply incorporated to your coverage for a small additional fee.

  1. Protection in case of an urgent situation

Throughout these daunting circumstances, immediate hospitalizations is frequently required due to sudden drops in oxygen concentration. This is a big concern in semi-urban and remote environments, where consistent public transportation at odd hours may be difficult. As a result, acquiring healthcare insurance while you’re COVID positive could be a lifesaver for you and your household.

How Do You File a Healthcare Insurance Claim?

A healthcare coverage program allows you to receive the best possible medical treatment without having to worry about the exorbitant costs that will be owing at the time of release. As a result, recognizing the claim process is an essential piece of detail for the protected individual to have. The two main types of health insurance applications that a person might choose from when filing a claim are listed below.

  • Procedure for submitting a repayment claim

The protected person hospitalized to a certain hospital supports the entire healthcare treatments until they are released in this repayment claim method. After the insured individual has paid for the healthcare treatments and hospitalization costs, they must file a claim with the insurance company for repayment.

The individual protected should provide the relevant hospital and medication expenses in order to receive a claim reimbursement. However, you should always present genuine bills when filing a reimbursement, as your insurance company will analyze your claim request and decide whether to approve or reject it.

  • Cashless claim process

Inside this cashless claim procedure, the covered individual will firstly get treatments within the hospital, and the health center will subsequently transmit the claim to your authorized insurance provider firm at the moment of release.

Because the modifications are made between the insurance provider and the health center, this cashless claim process is simple for the covered individual.

After considering all of the aforementioned factors, it is clear that the need for healthcare coverage has accelerated dramatically throughout the outbreak. In this era of disease-prone individuals and expensive medical procedures, health protection policies from Care Insurance are becoming increasingly important.

Continue Reading

HEALTH

3 Things You Must Know Before Cooking for a Crowd

Published

on

If you’re like most people, entertaining friends and family over the holidays can be a real stress.

On the surface, cooking for a crowd might seem harder than cooking for just a handful of people. Crowding the ingredients and utensils in the oven often leads to chaos and failure.

Even seasoned chefs go for failure when trying to cook for big gatherings.

And the question is, how do you handle cooking with others while still maintaining safety in the kitchen and keeping this experience positive?

We want to help, so keep reading about how to cook for a crowd successfully!

  1. Do Your Research

If you’re planning on cooking for a group of people, do your research first. This means finding out what the guests will like and dislike, as well as any dietary restrictions they may have.

And also, knowing how many people you will be cooking for is necessary, as this will affect the amount of food you need to prepare. This will help to ensure that everything goes smoothly on the day of the event.

  1. Plan Ahead and Make a List

To feed a crowd can be a daunting task, but it doesn’t have to be. Plan ahead and make a list of everything you’ll need to do and make sure you have all the ingredients and supplies you’ll need.

Keep in mind that you need to start cooking early so that you can avoid any last-minute rushes.

Cook familiar foods like perfectly cooked pork chops that you know everyone will like. If you’re serving alcohol, make sure you have enough for everyone and keep an eye on how much people are drinking.

Set up a buffet so people can help themselves and clean up as you go so you’re not stuck with a huge mess at the end of the night. With a little planning and preparation, serving a group can be a breeze.

Last but not least, make a list of what needs to be done and who will be doing it, and go over it with your helpers. That way, when things start to get chaotic, you can all refer back to the list and make sure everyone is doing their part.

  1. Ensure Everyone’s Safety

If you’re considering cooking for a large group of people, there are a few things you should keep in mind to ensure everyone’s safety. First, make sure you have enough space to work in and that your kitchen is well-ventilated.

Second, be aware of food allergies and try to accommodate as many as possible. Third, cook food thoroughly and avoid cross-contamination by using separate cutting boards and utensils for raw and cooked food.

Finally, be sure to keep hot food hot and cold food cold to avoid foodborne illness.

Happiness Is Cooking for a Crowd 

Some things to keep in mind before cooking for a large group of people include considering dietary restrictions, having enough utensils and cookware, and allowing enough time to properly prepare the food.

Keep your guests in mind when cooking and be sure to have a plan before starting to cook to avoid any stressful surprises.

Also, give yourself plenty of time to prep and cook. Most importantly, relax and enjoy yourself – cooking for a crowd can be a lot of fun!

Found this article helpful? If yes, then keep reading for more tips and guides.

Continue Reading

Trending