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What happens when the coronavirus enters your body? Why we react so differently

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The immune system protects us, but in the most serious cases of coronavirus it seems to be overreacting and counterproductive, as it happens in other diseases

From the cases that go unnoticed because they do not give symptoms until death: the range of reactions caused by SARS-CoV-2 is wide and perplexing. Why does the same infection have such disparate effects? If statistics tell us anything, it is that age has a lot to do with it. In the first decades of life, there are hardly any complications, although some specific cases are difficult to explain. On the other hand, as the years of the patient’s increase, hospital admissions, cases in the ICU and deaths multiply.

Can everything be explained by the existence of previous pathologies? Hypertension, diabetes and cardiovascular diseases have been identified as risk factors, but there is a more basic question: what does the immune system do when attacked by an external enemy. In the face of an unknown virus, an innate response occurs, and, later, when our defenses already recognize the pathogen, the adaptive response arrives, which acts specifically against that threat. However, something seems to be failing in the most serious patients of this new coronavirus in this second phase: an exaggerated response that ends up causing damage to the body and does not prevent the virus from multiplying.

Be very careful with the Covid-19 if you already suffer from these diseases

The SARS-CoV-2 coronavirus causes more serious cases and deaths in people suffering from other pathologies, but the mechanisms by which it occurs are unclear

“It is striking that there is a lot of heterogeneity in the clinic of this virus, and this may be related to a wide variety of immune responses, some are more effective and neutralize the virus, and others lead to the disease, ” José Manuel told Teknautas Bautista, a molecular biologist from the Complutense University of Madrid, “but we really still know very little, each virus can behave differently even if there are common characteristics among those of the same family.”

“Viruses behave differently in each individual and challenge their immune system, ” explains virologist Raúl Ortiz de Lejarazu, former director of the National Flu Center in Valladolid. “What happens in each body has to do with individual factors that we do not know well, we know in the flu and in other diseases already studied, but not in this coronavirus,” he admits.

As an example of the heterogeneity in the response to viruses, this expert gives an example he knows well: “ In the 2009 influenza A pandemic, it was soon seen that the obese reacted worse, among this group there were many more people who fell ill with seriously because they had a different inflammatory profile than people with normal weight. ”

How the immune system reacts

At the beginning of an infection, the innate response occurs — it is called that because it is common to all people against a pathogenic microorganism, even if we have not been exposed before. This works “by a very primary system: I know you or I don’t know you, you are strange or you are not .” If we do not recognize it, a series of mechanisms are set in motion, for example, we secrete proteins called interferons and cytokines. “If this occurs normally, the result is a good physiological response that tends to heal the individual,” explains the expert.

The next step is the adaptive response. “It is a response adapted to the new pathogen as if the tailor had already taken the measurements and made the right suit against the aggression, ” he says. That is why, in almost any infection, antibodies (substances to combat it) are generated from day 12 or 13, which makes the primary and innate response more effective.

However, severe cases of coronavirus appear to be related to an exaggerated response by the immune system, which experts call a “cytokine storm.” This term was coined around 15 years ago when serious cases of avian influenza in Asia were being investigated. People who reacted badly and died had secreted many inflammatory cytokines, that is, a type of protein that generates inflammatory phenomena indiscriminately in the lung and other organs. Instead of collaborating with each other, they “ generated friendly fire damage ”.

Ortiz de Lejarazu’s research group observed that the same was true in severe cases of influenza A, according to articles they published in 2011 and 2012. That cytokine storm also happens again in severe Covid-19 cases. “ Our immune system, in the effort to eliminate the virus, damages cells and organs. The end result is that it does not control the virus, which continues to multiply, “he says.

In very different diseases, it also occurs. Bautista knows the case of cerebral malaria thoroughly. “There are many people who become infected in Africa, but only a specific population group dies, children who react aggressively with their immune response. All this is very similar to what is being described ”, he points out.

Does exposure influence gravity?

Other external factors do not influence the fact that a patient reaches this serious situation, such as having been in greater contact with the disease, as happens to health professionals, according to Ortiz de Lejarazu, who warns about the confusion that is generating the viral load concept. “It is only a parameter used in medicine as if we were talking about fever. What the viral load tells us is whether a virus is multiplying too much or too little in an organism. For example, in HIV, the viral load is used to know if the person who is infected is responding well to treatments or if, on the contrary, the amount of virus in their body increases. ”

When one acquires the infecting dose, one becomes infected. If you buy three doses, 10 or 20, you get the same infection but you will not be more serious

However, in this crisis, this concept is being misrepresented, and some are implying that the virus can accumulate through continued exposure. “The toilets do not go with a backpack carrying viruses,” he clarifies, “a person becomes infected because they acquire an infectious dose, that is, a certain amount of microorganism.” Scientists calculate what viral load is needed for contagion in mouse experiments.

“When you get the infectious dose, you become infected. If you get three infectious doses, 10 or 20, you get the same infection, and that does not have any significance on what will happen next, because in reality on the second or third day of being infected, a person produces millions of infective doses. In the body, we amplify the infective dose a lot of times and there we do talk about the viral load. The only consequence of viral load is that a person who is producing more viruses has a greater ability to transmit them, “he adds.

On the other hand, José Manuel Bautista does not rule out that prolonged exposure to the virus could have something to do with severe cases. “If only a few units of the virus infect you, they could reach a few cells and perhaps the immune response would be activated progressively so that it could contain itself better,” he says. However, “this is only a hypothesis because no experiment has been done to prove it, to see if this is the case, it would be necessary to subject mice to different viral loads and that, as they increase, there comes a time when the answer immune was not efficient. ”

The coronavirus viral load appears to peak in the first week of illness, and in mild cases, it would clear rapidly. However, seriously ill patients tend to have a high viral load and a longer period of virus shedding, according to an article published in ‘The Lancet ‘. Therefore, the viral load could be a marker to assess severity and prognosis (although this is not related to the possibility that viral load is related to prolonged exposure).

In any case, in the absence of experiments that can confirm or deny this idea, the researcher at the Complutense University considers that the reason why health professionals get sick is more likely due to other factors, such as stress decreases their immune response.

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What should you watch out for in cold therapy?

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Cold therapy is also called cryotherapy. And this therapy is an application of physical medicine. This cold therapy can be used both systematically and locally. It is always intended for therapeutic purposes. The main area of ​​application is still to be used in traumatology. It has also become an integral part of rheumatology. Cold therapy can alleviate or prevent illness. The area of ​​application with cold therapy is broad.

The aim of the application
Cold therapy always has one aim and that would be to remove the heat from the tissue to be treated.  Muscular relaxation should also be achieved. Which then has the effect of taking the pain away.

The differences in application
there are basically two types of application of cold therapy. There is short-term use and long-term use. The various forms of therapy differ in very clear features. Of course, the effect also differs. The short-term application of cold therapy never lasts longer than 10-15 minutes. The result is that the blood flow to the deep and superficial muscles is locally reduced. After the cold is withdrawn again, the blood circulation is stimulated and strengthened and the tissue is warmed up. Long-term use takes between one and two hours. The cold therapy results in a significant reduction in body temperature. The blood circulation naturally also comes to a standstill. This application is usually used for inflammation.

In any case, the pain is completely eliminated. However, it must be taken into account that the bleeding will be inhibited. Blood pressure and heart rate will also clearly increase. As for cold therapy, it can be carried out in a variety of ways. In all applications, however, it is certain that the cold stimulus is present. As different as the methods are, as different are the temperatures of the refrigeration applications. The place of use and the duration of use can also differ greatly. It is important to ensure that only the affected area is exposed to the cold, and if ice packs are used, the area of ​​the skin must be covered. The rest of the body is ideally wrapped up warm. This is the only way to avoid catching a cold or getting hypothermic.

8 reasons why cold therapy is good for you:

1. Cold therapy strengthens the immune system 

Regular use of cold therapy can strengthen the immune system and prevent diseases. You can find more tips on how to strengthen your immune system.

2. It relieves pain 

Studies show that cold therapy has a pain-relieving effect. A cold application is used in particular for chronic and inflammatory joint diseases.

3 For depression, cold therapy can improve the state of mind

The cold reduces the production of the stress hormone cortisol. This can have a positive effect on mild depression.

 4 It promotes regeneration in athletes 

Through the application of cold, the stressed muscles are supplied with more blood and can therefore regenerate more quickly. If you have sore muscles,

5 Cold helps you lose weight 

Regular use can activate the brown fat cells in the body and thus burn them off. Have a look here if you want to know what exactly happens in the body when you lose weight.

6 Firms the connective tissue

Due to the improved blood circulation, the connective tissue can be tightened and a beautiful complexion is created.

7 Cold helps with insomnia

The reduced production of the stress hormone cortisol also has a positive effect on sleep. By the way.

8 Cold therapy increases general wellbeing 

Whether it’s the adrenaline or the endorphins, the subsequent warmth that flows through the body, or simply the feeling of having overcome yourself – after just a few minutes you will feel good!

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Is There Any Effect of Wedding Cake Strain

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Wedding Cake Strain

Despite its name, the Wedding Cake strain is not exactly a wedding cake, but rather earthy and sour. There is only a slight sweetness towards the end. Despite its deceiving name, the Wedding Cake strain is extremely potent, with THC levels around 27%.

As a guest at a wedding, your mind is firmly focused on the party, and you are thinking about guava cake and ice cream after the ceremony. It’s absolutely beautiful and all, but the initial union is so mind-numbing! The after-party may include marijuana, along with liberal amounts of alcohol, depending on who is getting married and what kind of guests are invited!

What Is the Wedding Cake Strain?

The Wedding Cake strain was created through a cross between Cherry Pie and Girl Scout Cookies (GSC). There are certain budsmen who believe it is actually a cross between Animal Mints and Triangle Kush. The strain was originally bred in Southern California. The breed was later brought to Colorado by a breeder called Kind Love. A variety of OG Kush bred by Darkheart Nursery, Skywalker strain is a cross between Mazar, Blueberry, and Blueberry. This strain was created from a clone that was developed by Dutch Passion Seeds. Skywalker OG strain features notes of citrus hops and spice. It induces mellow, euphoric effects and increases awareness and creativity.

Wedding Cake Aroma

Its alluring aroma is rewarded once you see past the earthy and doughy scent. Despite its backcrossed genetics, this strain retained the tart and sugary characteristics of its lineage.

Wedding Cake Flavor

When you smell this, you are surprised to find that the soil and sour flavors take over your taste buds. However, the sweetness comes through after a short time. To get the best flavor, we suggest using a vaporizer set to a low temperature.

Wedding Cake Appearance

The tops and sides of the calyxes are covered with trichomes. This weed has an aesthetic of sugar cookies with its pinkish-red and grape shades. There are many buds that look like teardrops. Wedding Cake is sometimes referred to as ‘Pink Cookie’ because of its pink color.

Wedding Cake Strain Grow Info

You cannot easily obtain Wedding Cake seeds. Due to the lack of growth information shared by its cultivators, growing this strain may require trial and error. Cuttings from female plants are best.

Allow a bit of humidity in the air with your fan and exhaust system. Flowering should occur between 7 and 9 weeks. Indoor yields range from 18-21 ounces per square meter.

When growing it outside, seek a warm, sunny, slightly humid climate. Use rich soil for growing. You should be able to harvest your crop by late September or mid-October. Outdoor Wedding Cake growers can expect a bounty of 21 ounces per plant.

THC Content – Highest Test

Wedding Cake has a reputation for being a powerhouse. These strains have been found to contain THC levels of 27%! 

CBD Content – Highest Test

In general, Wedding Cake contains approximately 0.1% CBD, rarely over 0.23%. Therefore, it commonly has a THC: CBD ratio of around 250:1. Beta-caryophyllene, more commonly found in plants with high CBD content, also creates a similar effect to Harlequin. Since Wedding Cake terpenes stimulate CB2 receptors, this strain is excellent for medicinal use.

What Are Wedding Cake’s Likely Effects?

Earlier, we mentioned that Wedding Cake was a very potent strain. As such, it’s probably not the best choice for an after-wedding party toke – unless you intend to head home soon afterward.

You’ll probably feel mildly psychedelic, and you’ll see everything in high definition! Beginners might find this a bit disconcerting, but experienced cannabis consumers shouldn’t find it too confusing. Fortunately, this strain is an excellent option for feeling relaxed and calm.

The effect of Wedding Cake Strain is that while standing right in the middle of a crowd, you will feel more like a spectator rather than a participant.

Medical Benefits of the Wedding Cake Strain

The Wedding Cake strain is used by some cannabis consumers to manage anxiety and depression due to its uplifting effects.

There is a popular marijuana strain called Wedding Cake that is commonly prescribed for pain associated with musculoskeletal conditions such as arthritis, sciatica, and fibromyalgia. As well as treating neurological conditions, the Wedding Cake strain is also used to relieve symptoms of Lou Gehrig’s disease.

Effects of the Wedding Cake Strain

The majority of high-THC strains can cause adverse side effects. The use of too much can lead to problems such as cottonmouth or red eyes. When suffering from predisposed anxiety or panic disorders, it can result in panic attacks in rare cases.

Final Thoughts on the Wedding Cake Strain

An intense strain, Wedding Cake can temporarily relieve pain, anxiety, and depression. You swear it tastes just like dabbing a concentrate! It has an extremely high level of THC! The strain is a relaxing smoke, but it may not be suitable for beginners or anyone who is sensitive to weed. Wedding Cakes with higher CBD content and lower THC levels are available. This may reduce the chance of experiencing side effects. Your mind will feel energized after using it, and you might break out into uncontrollable giggles. As a result of the relaxation, you may drift into a peaceful sleep.

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Small intestinal bacterial overgrowth (SIBO) treatment.

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Small intestinal bacterial overgrowth (SIBO) treatment.

Small intestinal bacterial overgrowth syndrome, also known by the acronym SBID, or SIBO, is a condition in which there is an overgrowth of bacteria in the small intestine, reaching values similar to the number of bacteria present in the large intestine.

Although bacteria are important for the digestion of food and absorption of nutrients, when they are in excess they can cause intestinal problems, which result in symptoms such as excessive gas, constant feeling of a bloated stomach, abdominal pain, and constant diarrhea, for example. Also, altering nutrient absorption, in some people can result in malnutrition, even if the person is eating correctly.

This syndrome is curable and can be treated, in many cases, with changes in diet and lifestyle, but it can also include the use of antibiotics prescribed by the gastroenterologist after doing a SIBO test.

Diagnosis

When several causes of gastrointestinal problems have been ruled out and a solution is found, the SIBO investigation must be carried out. Excess bacteria in the small intestine can lead to the release of hydrogen and methane gases, which can be identified through a breath test. This test is non-invasive and can be performed at home or in a doctor’s office. To take the exam, fasting is required. During the test, you will breathe into a tube. You will then drink a special sweet drink provided by your doctor. You will breathe into a series of additional tubes at regular intervals for 2-3 hours after drinking. If breath testing is not available, urinary metabolite tests can be performed or small bowel fluid samples can be collected for identification of bacteria.

How SIBO influences health status

Despite being a disorder that is not well understood and needs further study, it is known that it can occur when the small intestine has anatomical abnormalities, changes in pH, or poor muscle activity in its functions, which means that food and bacteria are not removed from the organ and consequently influence the immune system not to function properly.

SIBO symptoms are common to several gastrointestinal pathologies and can easily be confused with viral gastroenteritis or stomach disease, celiac disease, Crohn’s disease, hypochlorhydria, or low levels of stomach acid, gastroparesis, portal hypertension, or bowel syndrome is irritable. All have in common symptoms that mainly affect the intestine, such as stomach pain, especially after eating, bloating, cramps, diarrhea, constipation, indigestion, gas/flatulence, or regular feeling of fullness, but it can also lead to weight loss.

Nutritional support

Some patients with SIBO have associated weight loss or deficiencies in various vitamins or minerals. This can lead to deficiency syndromes. Most patients with SIBO will need supplementation with vitamin B12, fat-soluble vitamins, calcium, and magnesium. Lactase deficiency may be associated with SIBO due to mucosal inflammation of the brush boundary and therefore often prohibiting lactose-containing foods until the condition resolves. The low FODMAP diet, the specific carbohydrate diet, and the gut and psychology diet are some diets that are recommended in this condition.

Treatment of bacterial overgrowth

The keystone of SIBO treatment is of course antibiotic therapy, decreasing or even eradicating the excessive bacteria and thus decreasing the pathological mutations they cause in the small intestine. While the effect is often sufficiently directed to induce some researchers to support empirical antibiotics when the diagnosis is suspected, this can hinder the study of the disease due to:

• The significant cost of therapy

• The placebo effect which is large enough to be statistically significant

• The frequent need for multiple courses of antibiotics to manage overgrowth

• Potential complications of antibiotic treatment, such as drug resistance and adverse effects

In one study, a course of antibiotics could be expected to alleviate symptoms for 22 days on average so it would be impractical to consider antibiotic therapy alone in this condition, as it would require a minimum of 12 courses per year.

The most commonly used antibiotics for the treatment of SIBO are mostly chosen on the basis of experience, rather than sensitivity and culture studies, which would not be cost-effective. Among the first were tetracyclines, followed by the combination, ciprofloxacin, doxycycline, rifaximin which is a derivative of rifamycin, and amoxicillin-clavulanate metronidazole. Ciprofloxacin and metronidazole appear to be more effective, especially in SIBO associated with Crohn’s disease. However, all symptoms do not respond constantly.

Fabian-mueller.net is now exploring the treatment of SIBO, especially finding and eliminating the causes of SIBO, Displacement of colon germs and Build up a healthy flora in the small intestine, and support bowel function. While the initial results were positive with respect to lasting and reliable symptom relief, confirmatory work remains to be done.

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